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BridgeDB not matching properly #14

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jjgao opened this issue Feb 9, 2015 · 0 comments
Open

BridgeDB not matching properly #14

jjgao opened this issue Feb 9, 2015 · 0 comments

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@jjgao
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jjgao commented Feb 9, 2015

Reported from a user:

I just recently started to work with cytoscape and realized that BridgeDB eases my work a lot!
However, what puzzled me was the fact that quite a lot of IDs in my network could not be matched properly.
The BioGRID networks I am using use the gene/protein symbol as identifiers, however, all my files are based on EnsemblIDs.
So I now compared the matched IDs from BridgeDB (symbol->Ensembl) with a matched list from ensembl/biomart.
Apparently, there were quite a lot of IDs that could not be matched by BridgeDB (~250 out of 8000). Even worse, unfortunately, a lot of IDs were matched wrongly.
I figured out that in almost all cases were the IDs were matched incorrectly, the matched EnsemblID actually refers to another gene with almost similar symbols.
I.e. "Abp1" was matched to the Enseml of "Napb1",
"Cno" to the one of "Cnot11",
"Rod" to Neurod1" and so on.
All of them are no synonyms to each other, so I suppose it might be an error in the actual matchin procedure or the bridgedb database itself.
Is this already known?

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