diff --git a/Marlin/src/inc/Conditionals_post.h b/Marlin/src/inc/Conditionals_post.h
index e0007ab7b3f6..4f15621a254b 100644
--- a/Marlin/src/inc/Conditionals_post.h
+++ b/Marlin/src/inc/Conditionals_post.h
@@ -2567,10 +2567,21 @@
 
 #if ANY(HAS_AUTO_FAN_0, HAS_AUTO_FAN_1, HAS_AUTO_FAN_2, HAS_AUTO_FAN_3, HAS_AUTO_FAN_4, HAS_AUTO_FAN_5, HAS_AUTO_FAN_6, HAS_AUTO_FAN_7, HAS_AUTO_CHAMBER_FAN, HAS_AUTO_COOLER_FAN)
   #define HAS_AUTO_FAN 1
-#endif
-#define _FANOVERLAP(A,B) (A##_AUTO_FAN_PIN == E##B##_AUTO_FAN_PIN)
-#if HAS_AUTO_FAN && (_FANOVERLAP(CHAMBER,0) || _FANOVERLAP(CHAMBER,1) || _FANOVERLAP(CHAMBER,2) || _FANOVERLAP(CHAMBER,3) || _FANOVERLAP(CHAMBER,4) || _FANOVERLAP(CHAMBER,5) || _FANOVERLAP(CHAMBER,6) || _FANOVERLAP(CHAMBER,7))
-  #define AUTO_CHAMBER_IS_E 1
+  #define _FANOVERLAP(I,T) (T##_AUTO_FAN_PIN == E##I##_AUTO_FAN_PIN)
+  #if HAS_AUTO_CHAMBER_FAN
+    #define _CHFANOVERLAP(I) || _FANOVERLAP(I,CHAMBER)
+    #if (0 REPEAT(8, _CHFANOVERLAP))
+      #define AUTO_CHAMBER_IS_E 1
+    #endif
+    #undef _CHFANOVERLAP
+  #endif
+  #if HAS_AUTO_COOLER_FAN
+    #define _COFANOVERLAP(I) || _FANOVERLAP(I,COOLER)
+    #if (0 REPEAT(8, _COFANOVERLAP))
+      #define AUTO_COOLER_IS_E 1
+    #endif
+    #undef _COFANOVERLAP
+  #endif
 #endif
 
 // Fans check
@@ -2615,6 +2626,9 @@
 #if !HAS_AUTO_CHAMBER_FAN || AUTO_CHAMBER_IS_E
   #undef AUTO_POWER_CHAMBER_FAN
 #endif
+#if !HAS_AUTO_COOLER_FAN || AUTO_COOLER_IS_E
+  #undef AUTO_POWER_COOLER_FAN
+#endif
 
 // Print Cooling fans (limit)
 #ifdef NUM_M106_FANS
diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index 49fa1ea1a4a0..3db20987780c 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -2948,24 +2948,9 @@ static_assert(X_MAX_LENGTH >= X_BED_SIZE, "Movement bounds (X_MIN_POS, X_MAX_POS
  * Auto Fan check for PWM pins
  */
 #if HAS_AUTO_FAN && EXTRUDER_AUTO_FAN_SPEED != 255
-  #define AF_ERR_SUFF "_AUTO_FAN_PIN is not a PWM pin. Set EXTRUDER_AUTO_FAN_SPEED to 255."
-  #if HAS_AUTO_FAN_0
-    static_assert(_TEST_PWM(E0_AUTO_FAN_PIN), "E0" AF_ERR_SUFF);
-  #elif HAS_AUTO_FAN_1
-    static_assert(_TEST_PWM(E1_AUTO_FAN_PIN), "E1" AF_ERR_SUFF);
-  #elif HAS_AUTO_FAN_2
-    static_assert(_TEST_PWM(E2_AUTO_FAN_PIN), "E2" AF_ERR_SUFF);
-  #elif HAS_AUTO_FAN_3
-    static_assert(_TEST_PWM(E3_AUTO_FAN_PIN), "E3" AF_ERR_SUFF);
-  #elif HAS_AUTO_FAN_4
-    static_assert(_TEST_PWM(E4_AUTO_FAN_PIN), "E4" AF_ERR_SUFF);
-  #elif HAS_AUTO_FAN_5
-    static_assert(_TEST_PWM(E5_AUTO_FAN_PIN), "E5" AF_ERR_SUFF);
-  #elif HAS_AUTO_FAN_6
-    static_assert(_TEST_PWM(E6_AUTO_FAN_PIN), "E6" AF_ERR_SUFF);
-  #elif HAS_AUTO_FAN_7
-    static_assert(_TEST_PWM(E7_AUTO_FAN_PIN), "E7" AF_ERR_SUFF);
-  #endif
+  #define AF_ASSERT(N) OPTCODE(HAS_AUTO_FAN_##N, static_assert(_TEST_PWM(E##N##_AUTO_FAN_PIN), "E" STRINGIFY(N) "_AUTO_FAN_PIN is not a PWM pin. Set EXTRUDER_AUTO_FAN_SPEED to 255."))
+  REPEAT(8, AF_ASSERT)
+  #undef AF_ASSERT
 #endif
 
 /**
diff --git a/Marlin/src/module/temperature.cpp b/Marlin/src/module/temperature.cpp
index 07a4752002c4..ffe3dcc03dae 100644
--- a/Marlin/src/module/temperature.cpp
+++ b/Marlin/src/module/temperature.cpp
@@ -1166,44 +1166,55 @@ int16_t Temperature::getHeaterPower(const heater_id_t heater_id) {
   }
 }
 
-#define _EFANOVERLAP(A,B) _FANOVERLAP(E##A,B)
-
 #if HAS_AUTO_FAN
 
+  #define _EFANOVERLAP(I,N) ((I != N) && _FANOVERLAP(I,E##N))
+
   #if EXTRUDER_AUTO_FAN_SPEED != 255
-    #define INIT_E_AUTO_FAN_PIN(P) do{ if (P == FAN1_PIN || P == FAN2_PIN) { SET_PWM(P); SET_FAST_PWM_FREQ(P); } else SET_OUTPUT(P); }while(0)
+    #define INIT_E_AUTO_FAN_PIN(P) do{ if (PWM_PIN(P)) { SET_PWM(P); SET_FAST_PWM_FREQ(P); } else SET_OUTPUT(P); }while(0)
   #else
     #define INIT_E_AUTO_FAN_PIN(P) SET_OUTPUT(P)
   #endif
   #if CHAMBER_AUTO_FAN_SPEED != 255
-    #define INIT_CHAMBER_AUTO_FAN_PIN(P) do{ if (P == FAN1_PIN || P == FAN2_PIN) { SET_PWM(P); SET_FAST_PWM_FREQ(P); } else SET_OUTPUT(P); }while(0)
+    #define INIT_CHAMBER_AUTO_FAN_PIN(P) do{ if (PWM_PIN(P)) { SET_PWM(P); SET_FAST_PWM_FREQ(P); } else SET_OUTPUT(P); }while(0)
   #else
     #define INIT_CHAMBER_AUTO_FAN_PIN(P) SET_OUTPUT(P)
   #endif
+  #if COOLER_AUTO_FAN_SPEED != 255
+    #define INIT_COOLER_AUTO_FAN_PIN(P) do{ if (PWM_PIN(P)) { SET_PWM(P); SET_FAST_PWM_FREQ(P); } else SET_OUTPUT(P); }while(0)
+  #else
+    #define INIT_COOLER_AUTO_FAN_PIN(P) SET_OUTPUT(P)
+  #endif
 
   #ifndef CHAMBER_FAN_INDEX
     #define CHAMBER_FAN_INDEX HOTENDS
   #endif
 
   void Temperature::update_autofans() {
-    #define _EFAN(B,A) _EFANOVERLAP(A,B) ? B :
+    #define _EFAN(I,N) _EFANOVERLAP(I,N) ? I :
     static const uint8_t fanBit[] PROGMEM = {
       0
       #if HAS_MULTI_HOTEND
         #define _NEXT_FAN(N) , REPEAT2(N,_EFAN,N) N
         RREPEAT_S(1, HOTENDS, _NEXT_FAN)
       #endif
+      #define _NFAN HOTENDS
       #if HAS_AUTO_CHAMBER_FAN
-        #define _CFAN(B) _FANOVERLAP(CHAMBER,B) ? B :
-        , REPEAT(HOTENDS,_CFAN) (HOTENDS)
+        #define _CHFAN(I) _FANOVERLAP(I,CHAMBER) ? I :
+        , (REPEAT(HOTENDS,_CHFAN) (_NFAN))
+        #undef _NFAN
+        #define _NFAN INCREMENT(HOTENDS)
+      #endif
+      #if HAS_AUTO_COOLER_FAN
+        #define _COFAN(I) _FANOVERLAP(I,COOLER) ? I :
+        , (REPEAT(HOTENDS,_COFAN) (_NFAN))
       #endif
     };
 
     uint8_t fanState = 0;
     HOTEND_LOOP() {
-      if (temp_hotend[e].celsius >= EXTRUDER_AUTO_FAN_TEMPERATURE) {
+      if (temp_hotend[e].celsius >= EXTRUDER_AUTO_FAN_TEMPERATURE)
         SBI(fanState, pgm_read_byte(&fanBit[e]));
-      }
     }
 
     #if HAS_AUTO_CHAMBER_FAN
@@ -1234,6 +1245,11 @@ int16_t Temperature::getHeaterPower(const heater_id_t heater_id) {
             chamberfan_speed = fan_on ? CHAMBER_AUTO_FAN_SPEED : 0;
             break;
         #endif
+        #if ENABLED(AUTO_POWER_COOLER_FAN)
+          case COOLER_FAN_INDEX:
+            coolerfan_speed = fan_on ? COOLER_AUTO_FAN_SPEED : 0;
+            break;
+        #endif
         default:
           #if EITHER(AUTO_POWER_E_FANS, HAS_FANCHECK)
             autofan_speed[realFan] = fan_on ? EXTRUDER_AUTO_FAN_SPEED : 0;
@@ -1247,35 +1263,16 @@ int16_t Temperature::getHeaterPower(const heater_id_t heater_id) {
         #define _AUTOFAN_SPEED() EXTRUDER_AUTO_FAN_SPEED
       #endif
       #define _AUTOFAN_CASE(N) case N: _UPDATE_AUTO_FAN(E##N, fan_on, _AUTOFAN_SPEED()); break
+      #define AUTOFAN_CASE(N) OPTCODE(HAS_AUTO_FAN_##N, _AUTOFAN_CASE(N))
 
       switch (f) {
-        #if HAS_AUTO_FAN_0
-          _AUTOFAN_CASE(0);
-        #endif
-        #if HAS_AUTO_FAN_1
-          _AUTOFAN_CASE(1);
-        #endif
-        #if HAS_AUTO_FAN_2
-          _AUTOFAN_CASE(2);
-        #endif
-        #if HAS_AUTO_FAN_3
-          _AUTOFAN_CASE(3);
-        #endif
-        #if HAS_AUTO_FAN_4
-          _AUTOFAN_CASE(4);
-        #endif
-        #if HAS_AUTO_FAN_5
-          _AUTOFAN_CASE(5);
-        #endif
-        #if HAS_AUTO_FAN_6
-          _AUTOFAN_CASE(6);
-        #endif
-        #if HAS_AUTO_FAN_7
-          _AUTOFAN_CASE(7);
-        #endif
+        REPEAT(8, AUTOFAN_CASE)
         #if HAS_AUTO_CHAMBER_FAN && !AUTO_CHAMBER_IS_E
           case CHAMBER_FAN_INDEX: _UPDATE_AUTO_FAN(CHAMBER, fan_on, CHAMBER_AUTO_FAN_SPEED); break;
         #endif
+        #if HAS_AUTO_COOLER_FAN && !AUTO_COOLER_IS_E
+          case COOLER_FAN_INDEX: _UPDATE_AUTO_FAN(COOLER, fan_on, COOLER_AUTO_FAN_SPEED); break;
+        #endif
       }
       SBI(fanDone, realFan);
     }
@@ -2704,33 +2701,39 @@ void Temperature::init() {
   HAL_timer_start(MF_TIMER_TEMP, TEMP_TIMER_FREQUENCY);
   ENABLE_TEMPERATURE_INTERRUPT();
 
-  #if HAS_AUTO_FAN_0
-    INIT_E_AUTO_FAN_PIN(E0_AUTO_FAN_PIN);
-  #endif
-  #if HAS_AUTO_FAN_1 && !_EFANOVERLAP(1,0)
-    INIT_E_AUTO_FAN_PIN(E1_AUTO_FAN_PIN);
-  #endif
-  #if HAS_AUTO_FAN_2 && !(_EFANOVERLAP(2,0) || _EFANOVERLAP(2,1))
-    INIT_E_AUTO_FAN_PIN(E2_AUTO_FAN_PIN);
-  #endif
-  #if HAS_AUTO_FAN_3 && !(_EFANOVERLAP(3,0) || _EFANOVERLAP(3,1) || _EFANOVERLAP(3,2))
-    INIT_E_AUTO_FAN_PIN(E3_AUTO_FAN_PIN);
-  #endif
-  #if HAS_AUTO_FAN_4 && !(_EFANOVERLAP(4,0) || _EFANOVERLAP(4,1) || _EFANOVERLAP(4,2) || _EFANOVERLAP(4,3))
-    INIT_E_AUTO_FAN_PIN(E4_AUTO_FAN_PIN);
-  #endif
-  #if HAS_AUTO_FAN_5 && !(_EFANOVERLAP(5,0) || _EFANOVERLAP(5,1) || _EFANOVERLAP(5,2) || _EFANOVERLAP(5,3) || _EFANOVERLAP(5,4))
-    INIT_E_AUTO_FAN_PIN(E5_AUTO_FAN_PIN);
-  #endif
-  #if HAS_AUTO_FAN_6 && !(_EFANOVERLAP(6,0) || _EFANOVERLAP(6,1) || _EFANOVERLAP(6,2) || _EFANOVERLAP(6,3) || _EFANOVERLAP(6,4) || _EFANOVERLAP(6,5))
-    INIT_E_AUTO_FAN_PIN(E6_AUTO_FAN_PIN);
-  #endif
-  #if HAS_AUTO_FAN_7 && !(_EFANOVERLAP(7,0) || _EFANOVERLAP(7,1) || _EFANOVERLAP(7,2) || _EFANOVERLAP(7,3) || _EFANOVERLAP(7,4) || _EFANOVERLAP(7,5) || _EFANOVERLAP(7,6))
-    INIT_E_AUTO_FAN_PIN(E7_AUTO_FAN_PIN);
-  #endif
-  #if HAS_AUTO_CHAMBER_FAN && !AUTO_CHAMBER_IS_E
-    INIT_CHAMBER_AUTO_FAN_PIN(CHAMBER_AUTO_FAN_PIN);
-  #endif
+  #if HAS_AUTO_FAN
+    #define _OREFAN(I,N) || _EFANOVERLAP(I,N)
+    #if HAS_AUTO_FAN_0
+      INIT_E_AUTO_FAN_PIN(E0_AUTO_FAN_PIN);
+    #endif
+    #if HAS_AUTO_FAN_1 && !_EFANOVERLAP(0,1)
+      INIT_E_AUTO_FAN_PIN(E1_AUTO_FAN_PIN);
+    #endif
+    #if HAS_AUTO_FAN_2 && !(0 REPEAT2(2, _OREFAN, 2))
+      INIT_E_AUTO_FAN_PIN(E2_AUTO_FAN_PIN);
+    #endif
+    #if HAS_AUTO_FAN_3 && !(0 REPEAT2(3, _OREFAN, 3))
+      INIT_E_AUTO_FAN_PIN(E3_AUTO_FAN_PIN);
+    #endif
+    #if HAS_AUTO_FAN_4 && !(0 REPEAT2(4, _OREFAN, 4))
+      INIT_E_AUTO_FAN_PIN(E4_AUTO_FAN_PIN);
+    #endif
+    #if HAS_AUTO_FAN_5 && !(0 REPEAT2(5, _OREFAN, 5))
+      INIT_E_AUTO_FAN_PIN(E5_AUTO_FAN_PIN);
+    #endif
+    #if HAS_AUTO_FAN_6 && !(0 REPEAT2(6, _OREFAN, 6))
+      INIT_E_AUTO_FAN_PIN(E6_AUTO_FAN_PIN);
+    #endif
+    #if HAS_AUTO_FAN_7 && !(0 REPEAT2(7, _OREFAN, 7))
+      INIT_E_AUTO_FAN_PIN(E7_AUTO_FAN_PIN);
+    #endif
+    #if HAS_AUTO_CHAMBER_FAN && !AUTO_CHAMBER_IS_E
+      INIT_CHAMBER_AUTO_FAN_PIN(CHAMBER_AUTO_FAN_PIN);
+    #endif
+    #if HAS_AUTO_COOLER_FAN && !AUTO_COOLER_IS_E
+      INIT_COOLER_AUTO_FAN_PIN(COOLER_AUTO_FAN_PIN);
+    #endif
+  #endif // HAS_AUTO_FAN
 
   #if HAS_HOTEND
     #define _TEMP_MIN_E(NR) do{ \